The ASIT+TM products are based the ASIT biotech proprietary technology platform. The lead product gp-ASIT+TM for grass pollen rhinitis is currently in phase III. The preclinical development of hdm-ASIT+TM  ( for house dust mite rhinitis) and  pnt-ASIT+TM  (for peanut allergy) are completed. Other ASIT+TM product candidates are currently in discovery phase.

Asit milestones 8b21e

ASIT biotech’ ASIT+TM products are innovative, designed to avoid the limitations of existing immunotherapy products and to satisfy expectations of patients and health care providers in terms of efficacy, safety and easiness of use.

The preclinical, clinical and production process of gp-ASIT+TM for the treatment of allergic rhinitis is aplicable to the development of allergen fragments from other allergens such as house dust mite, ragweed and food allergens like peanut and egg white. The flexibility of the platform allows adapting the process to the particular characteristics of a specific allergen.

gp-ASIT+TM for the treatment of grass pollen rhinitis

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ASIT biotechs’ strategy is to develop products to satisfy unmet medical needs, so the target population of gp-ASIT+TM are those suffering from moderate-to-severe allergic rhinitis. The fact that one third of the patients suffering from moderate-severe allergic rhinitis also have asthma will improve the medico-economic impact of gp-ASIT+TM.

The target product profile of gp-ASIT+TM product candidate consists among others of:

- a ready to use natural allergen-fragment based product;
- an adjuvant free product; a safety profile in line with best-in-class products;
- a relatively short treatment schedule with a maximum of 4 treatment visits over 3 weeks, prior to allergen exposure;
- a rapid onset of action, both on symptomatic and immunological parameters; and a superior clinical efficacy during natural grass pollen exposure.

The safety, the immunogenicity and the potential clinical efficacy of gp-ASIT+TM using subcutaneous delivery have been confirmed in phase I, phase IIa, phase IIb and Phase III clinical trials in patients with grass pollen rhinitis.

Scientific publications

June 18 - 21, 2017: EAACI 2017, Helsinki

Poster: Efficacy of a 3-week subcutaneous immunotherapy course in patients with grass pollen-induced rhinoconjunctivitis: Results of a phase-3 study

Oral presentation: Short Course treatment of Subcutaneous Peptide Hydrolysate from Lolium Perenne - gp-ASIT+TM - suppresses Basophil Responses and induces IgG-associated Blocking Antibodies: A RDPCT


hdm-ASIT+TM for the treatment of house dust mite asthma

portfolioAsthm

hdm-ASIT+TM has the potential to revolutionize the treatment of underlying allergen sensitization in asthmatic patients through a convenient, safe, short-course treatment which would decrease asthma exacerbations, reduce usage of rescue medication (short-acting β2-agonists and inhaled corticosteroids), reduce hospitalizations and emergency room visits, and strongly reduce absenteeism and improve productivity. This is predicated on hdm-ASIT+TM significantly reducing asthma exacerbations due to allergen exposure, and decreasing the economic consequences of these attacks (emergency department visits or hospitalizations, use of rescue medications, physician visits, etc.).

The product candidate consists of a mixture of natural peptides (ranging from 1,000 to 10,000 kDa) obtained from the purified specific allergen extracted from Dermatophagoïdes pteronyssinus bodies.

The product is supplied as ready to use, sterile and stable solution, which contains no adjuvants or preservatives. As for gp-ASIT+TM product, the different doses to be administered are obtained by increasing the volume of the injected solution.

 

 

pnt-ASIT+TM for the treatment of peanut allergy

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pnt-ASIT+™ is the first product candidate of ASIT biotech against food allergies specifically targeting peanut allergy. 

It is the first peptide-based product for immunotherapy of food allergy, using ASIT+™ platform.

The first in vitro tests showed that these peptides trigger less of an allergic reaction than full allergens while rapidly stimulating the appropriate immune system regulating mechanisms.

Other Indications

The Company expects to start research and development on new product candidates (allergies to birtch, Japanese Cedar, egg white, cow milk, etc.) on demand, together with partners.